Article publié dans GLOBAL ADVANCES IN HEALTH AND MEDICINE
Volume 4, Numéro 3 • Juillet 2014
Cancer is a complex disorder whose detection and monitoring remains challenging. A biological modeling system, the biology of functions (BoF), claims to be able to evaluate physiologic elements related to carcinogenic activity. A pilot study as undertaken to evaluate the accuracy of the BoF in detecting differences between cancer cases and matched controls.
Materials and Method
A retrospective case control study was performed using the BoF analyses of 46 patients with active or inactive cancer (total cases) and 46 controls from a single private practice. The standard BoF panel of 17 biomarkers was evaluated. Sixty-two of 150 BoF indices derived from these biomarkers were pre-selected for analysis based on their relationship to cancer physiology. The data was analyzed with the Wilcoxon Signed Ranks Test using SPSS software.
Of the 62 indices, 7 were found to be statistically significant in comparing total cancer cases to controls :
- Estrogen Fraction #5,
- Comparative Genital Androgeny,
In a small retrospective case control study, statistically significant differences were found between cancer cases and controls in 7 BoF indices. These indices are indicators of physiological conditions consistent with cancer growth. These results warrant further study of this biological modeling system in cancer patients.
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